Category Archives: Symbolic names

Legal liability (Intentional creation of)


Legal liability 

Legal liability is the legal bound obligation to pay debts.[1]

  • In law a person is said to be legally liable when they are financially and legally responsible for something. Legal liability concerns both civil law and criminal law. See Strict liability. Under English law, with the passing of the Theft Act 1978, it is an offense to evade a liability dishonestly. Payment of damages usually resolved the liability. Vicarious liability arises under the common law doctrine of agencyrespondeat superior – the responsibility of the superior for the acts of their subordinate.
  • In commercial law, limited liability is a form of business ownership in which business owners are legally responsible for no more than the amount that they have contributed to a venture. If for example, a business goes bankrupt an owner with limited liability will not lose unrelated assets such as a personal residence (assuming they do not give personal guarantees). This is the standard model for larger businesses, in which a shareholder will only lose the amount invested (in the form of stock value decreasing). For an explanation see business entity.
  • Manufacturer’s liability is a legal concept in most countries that reflects the fact that producers have a responsibility not to sell a defective product. See product liability.

Stelazine


Trifluoperazine

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Trifluoperazine
Systematic (IUPAC) name
10-[3-(4-methylpiperazin-1-yl)propyl]-
2-(trifluoromethyl)-10H-phenothiazine
Identifiers
CAS number 117-89-5
ATC code N05AB06
PubChem CID 5566
IUPHAR ligand ID 214
DrugBank DB00831
Chemical data
Formula C21H24F3N3S 
Mol. mass 407.497
Pharmacokinetic data
Metabolism Hepatic
Half-life 10–20 hours
Therapeutic considerations
Pregnancy cat. C(AU) C(US)
Legal status POM (UK) -only (US)
Routes oral, IM
 Yes(what is this?)  (verify)Y
Trifluoperazine (Eskazinyl, Eskazine, Jatroneural, Modalina, Stelazine, Terfluzine, Trifluoperaz, Triftazin) is a typical antipsychotic of the phenothiazine chemical class.

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[edit] Uses

The primary indication of trifluoperazine is schizophrenia. Other official indications may vary country by country, but generally it is also indicated for use in agitation and patients with behavioural problems, severe nausea and vomiting as well as severe anxiety. Its use in many parts of the world has declined because of highly frequent and severe early and late tardive dyskinesia, a type of extrapyramidal symptom. The annual development rate of tardive dyskinesia may be as high as 4%.[citation needed]
A 2006 study suggested that trifluoperazine may be able to reverse addiction to opioids.[1]
A multi-year UK study by the Alzheimer’s Research Trust suggested that this and other antipsychotic drugs commonly given to Alzheimer’s patients with mild behavioural problems often make their condition worse.[2] The study concluded that
For most patients with AD, withdrawal of neuroleptics had no overall detrimental effect on functional and cognitive status and by some measures improved functional and cognitive status. Neuroleptics may have some value in the maintenance treatment of more severe neuropsychiatric symptoms, but this possibility must be weighed against the unwanted effects of therapy. The current study helps to inform a clinical management strategy for current practice, but the considerable risks of maintenance therapy highlight the urgency of further work to find, develop, and implement safer and more effective treatment approaches for neuropsychiatric symptoms in people with AD.

[edit] Pharmacology

Trifluoperazine has central antiadrenergic,[3] antidopaminergic,[4][5] and minimal anticholinergic effects.[6] It is believed to work by blockading dopamine D1 and D2 receptors in the mesocortical and mesolimbic pathways, relieving or minimizing such symptoms of schizophrenia as hallucinations, delusions, and disorganized thought and speech.[7]

[edit] Side effects

A 2004 meta-analysis of the studies on trifluoperazine found that it is more likely than placebo to cause extrapyramidal side effects such as akathisia, dystonia, and Parkinsonism.[7] It is also more likely to cause somnolence and anticholinergic side effects such as blurred vision and xerostomia (dry mouth).[7] All phenothiazines can cause the rare and sometimes fatal neuroleptic malignant syndrome.[8] Trifluoperazine can lower the seizure threshold.[9] The antimuscarinic action of trifluoperazine can cause excessive dilation of the pupils (mydriasis), which increases the chances of patients with hyperopia developing glaucoma.[10]

Johnson and Johnson


Johnson & Johnson

Johnson & Johnson
Type Public (NYSEJNJ)
Dow Jones Industrial Average Component
Industry Major drugs
Health care

Soaps

Shampoos
Founded 1886
Founder(s) Robert Wood Johnson I
James Wood Johnson

Edward Mead Johnson
Headquarters New Brunswick, NJ, U.S.
Area served Worldwide
Key people William C. Weldon
(Chairman) & (CEO)
Products Pharmaceuticals
Medical devices

Health care products
Toiletries

Soaps

Shampoos
, etc.
Revenue US$61.9 Billion (FY 2009)[1]
Operating income US$15.7 Billion (FY 2009)[1]
Net income US$12.3 Billion (FY 2009)[1]
Total assets US$94.7 Billion (FY 2009)[2]
Total equity US$50.6 Billion (FY 2009)[2]
Employees 118,700 (2009)[3]
Website JNJ.com also JJ.com
Johnson & Johnson (NYSEJNJ) is a global American pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500. Johnson & Johnson is known for its corporate reputation, consistently ranking at the top of Harris Interactive‘s National Corporate Reputation Survey,[4] ranking as the world’s most respected company by Barron’s Magazine,[5] and was the first corporation awarded the Benjamin Franklin Award for Public Diplomacy by the U.S. State Department for its funding of international education programs.[6] A suit brought by the United States Department of Justice in 2010, however, alleges that the company from 1999 to 2004 illegally marketed drugs to Omnicare, a pharmacy that dispenses the drugs in nursing homes.[7]
The corporation’s headquarters is located in New Brunswick, New Jersey, United States. Its consumerSkillman, New Jersey. The corporation includes some 250 subsidiary companies with operations in over 57 countries. Its products are sold in over 175 countries. J&J had worldwide pharmaceutical sales of $24.6 billion for the full-year 2008. division is located in
Johnson & Johnson’s brands include numerous household names of medications and first aid supplies. Among its well-known consumer products are the Band-Aid Brand line of bandages, Tylenol medications, Johnson’s baby products, Neutrogena skin and beauty products, Clean & Clear facial wash and Acuvue contact lenses

Eli Lilly


Eli Lilly

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Eli Lilly

Colonel Eli Lilly in 1885
Born July 8, 1838(1838-07-08) Baltimore, Maryland
Died June 6, 1898 (aged 59)
Indianapolis
, Indiana
Cause of death Cancer
Resting place Crown Hill Cemetery
Indianapolis
, Indiana
Nationality American
Education Pharmacology
Alma mater Asbury College
Occupation Pharmaceutical Chemist
Soldier

Industrialist
Known for Eli Lilly & co.
Philanthropy
Home town Indianapolis, Indiana
Title Colonel
Political party Republican
Religion Methodist
Spouse Emily Lemen (1860–1866)
Maria Cynthia Sloan (1869–1898)
Children Josiah K. Lilly, Sr.
Parents Esther & Gustavus Lilly
Relatives Eli Lilly (Grandson)
Josiah K. Lilly, Jr.
(Grandson)
Signature
Eli Lilly (July 8, 1838 – June 6, 1898) was an American soldier, pharmaceutical chemist, industrialist, entrepreneur, and founder of the Eli Lilly and Company pharmaceutical corporation. Lilly enlisted in the Union Army during the American Civil War; he recruited a company of men to serve with him in an artillery battery, was later promoted to colonel, and was given command of a cavalry unit. He was captured near the end of the war and held as a prisoner of war until its conclusion. After the war, he attempted to run a plantation in Mississippi, but failed and returned to his pharmacy profession after the death of his wife. Lilly remarried and worked in several pharmacies with partners before opening his own business in 1876 with plans to manufacture drugs and market them wholesale to pharmacies.
His company was successful and he soon became wealthy after making numerous advances in medicinal drug manufacturing. Two of the early advances he pioneered were creating gelatin capsules to hold medicine and fruit flavoring for liquid medicines. Eli Lilly & Company was one of the first pharmaceutical firms of its kind; it staffed a dedicated research department and put in place numerous quality-assurance measures.
Using his wealth, Lilly engaged in numerous philanthropic pursuits. He turned over the management of the company to his son in 1890 allowing himself to continue his engagement in charity and civic advancement in his primary focus. He helped found the organization that became the Indianapolis Chamber of Commerce, was the primary patron of Indiana’s branch of the Charity Organization Society, and personally funded the creation of the city’s children’s hospital which was later expanded by the state to become the Riley Children’s Hospital. He continued his active involvement with many organizations until his death from cancer in 1898.
Lilly was an advocate of federal regulation of the pharmaceutical industry, and many of his suggested reforms were enacted into law in 1906, resulting in the creation of the Food and Drug Administration. He was also among the pioneers of the concept of prescriptions, and helped form what became the common practice of giving addictive or dangerous medicines only to people who had first seen a physician. The company he founded has since grown into one of the largest and most influential pharmaceutical corporations in the world, and the largest corporation in Indiana. Using the wealth generated by the company, his son and grandsons created the Lilly Endowment to continue Lilly’s legacy of philanthropy. The endowment remains one of the largest charitable benefactors in the world.

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AstraZeneca


AstraZeneca

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AstraZeneca plc
Type Public limited company
(LSE: AZN, NASDAQAZN, OMXAZN)
Industry Pharmaceutical
Founded 6 April 1999 by merger
Headquarters London, United Kingdom
Key people Louis Schweitzer, Chairman
David R. Brennan, Chief Executive Officer[1]
Products Pharmaceutical products for humans
Revenue $32,804 million (2009)[2]
Operating income $11,543 million (2009)[2]
Net income $7,544 million (2009)[2]
Total assets US$46.8 Billion (FY 2009)[3]
Total equity US$15.9 Billion (FY 2009)[3]
Employees 62,000 (2010)[4]
Website astrazeneca.com
AstraZeneca plc[5] (LSE: AZN, NYSEAZN, OMXAZN) is a global pharmaceutical and biologicscompany headquartered in London, United Kingdom. It is the world’s seventh largest pharmaceutical company measured by revenues and has operations in over 100 countries.[6][7] It has a portfolio of products for major disease areas including cancer, cardiovascular, gastrointestinal, infection, neuroscience, respiratoryinflammation.[4] and
Its primary listing is on the London Stock Exchange and it is a constituent of the FTSE 100 Index. It has secondary listings on the New York Stock Exchange and the OMX exchange.

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Lexus


Lexus

Lexus
Type Division
Industry Automotive industry
Founded 1989
Founder(s) Eiji Toyoda
Headquarters Toyota, Aichi, Japan
Area served Worldwide
Key people Kazuo Ohara (MO)
Vince Socco (VP, Asia Pacific)
Andy Pfeiffenberger (VP, EU)
Mark Templin (VP, U.S.)
Products Automobiles
Services Automotive financing
Parent Toyota Motor Corporation (TYO: 7203)
(NYSETM)
Divisions F marque
Website Lexus.com
Lexus.co.uk

Lexus.eu

Lexus.jp
Lexus is the luxury vehicle division of Japanese automaker Toyota Motor Corporation. First introduced in 1989 in the United States, Lexus is now sold globally and has become Japan’s largest-selling make of premium cars. As of 2009, Lexus vehicles are officially marketed in over 70 countries and territories worldwide.[1] The Lexus marque has ranked among the ten largest Japanese global brands in market value.[2]Toyota, Aichi, Japan, with operational centers in Brussels, Belgium, and Torrance, California, United States. The division’s world headquarters are located in
Lexus originated from a clandestine flagship sedan project that began in 1983. This effort developed into the original Lexus LS, which was the first vehicle to wear the Lexus marque upon its launch in 1989. In following years, Lexus added sedan, coupé, convertible, and SUV models. In 2005, a hybrid version of the RXF marque performance division with the arrival of the IS F sport sedan. crossover debuted, and additional hybrid models were subsequently introduced to the Lexus lineup. In 2007, Lexus launched its
From the start of production, Lexus vehicles have been consistently produced in Japan, with manufacturing centered in the Chūbu and Kyūshū regions, and in particular at Toyota’s Tahara, Aichi, Chūbu and Miyata, Fukuoka, Kyūshū plants. Assembly of the first Lexus built outside the country, the Ontario, Canada-produced RX 330, began in 2003. Following a corporate reorganization from 2001 to 2005, Lexus also operates its own design, engineering, and manufacturing centers, solely responsible for the division’s vehicles.
Since the 2000s, Lexus has increased sales outside its largest market in the United States through an ongoing global expansion. The division inaugurated dealerships in Japan’s domestic market in 2005, becoming the first Japanese premium car marque to launch in its country of origin.[3] Further debuts in Southeast Asia, Latin America, and other export regions have since followed. The division’s lineup has also been expanded to reflect regional specifications in model and powertrain configurations.

Freddie Mercury


Freddie Mercury

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Freddie Mercury

Mercury performing in New Haven, CT, 1977
Background information
Birth name Farrokh Bulsara
Born 5 September 1946(1946-09-05) Stone Town, Zanzibar
Origin London, England, UK[1]
Died 24 November 1991 (aged 45)
Kensington
, London, England, United Kingdom
Genres Rock, Hard rock
Occupations Musician, singer-songwriter, record producer
Instruments Vocals, piano, keyboards, guitar
Years active 1969–91
Labels Columbia, Polydor, EMI, Parlophone, Hollywood Records
Associated acts Queen, Wreckage/Ibex, Montserrat Caballé
Freddie Mercury (born Farrokh Bulsara (Gujarati: ફ્રારુક બુલ્સારા‌), 5 September 1946 – 24 November 1991)[2] was a British musician, best known as the lead vocalist and a songwriter of the rock band Queen. As a performer, he was known for his flamboyant stage persona and powerful vocals over a four-octave range.[3][4][5] As a songwriter, Mercury composed many hits for Queen, including “Bohemian Rhapsody“, “Killer Queen“, “Somebody to Love“, “Don’t Stop Me Now“, “Crazy Little Thing Called Love” and “We Are the Champions“. In addition to his work with Queen, he led a solo career, penning hits such as “Barcelona“, “I Was Born to Love You” and “Living on My Own“. Mercury also occasionally served as a producer and guest musician (piano or vocals) for other artists.
Mercury, who was a Parsi born in Zanzibar and grew up there and in India until his mid-teens, has been referred to as “Britain’s first Asian rock star”.[6] He died of bronchopneumonia brought on by AIDS on 24 November 1991, only one day after publicly acknowledging he had the disease. In 2006, Time Asia named him as one of the most influential Asian heroes of the past 60 years,[7] and he continues to be voted one of the greatest singers in the history of popular music. In 2005, a poll organised by Blender and MTV2 saw Mercury voted the greatest male singer of all time.[8] In 2009, a Classic Rock poll saw him voted the greatest rock singer of all time.[9] In 2008, Rolling Stone editors ranked him number 18 on their list of the 100 greatest singers of all time.[4] Allmusic has characterised Mercury as “one of the most dynamic and charismatic frontmen in rock history.”[10]

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Early life

The house in Zanzibar where Mercury lived in his early years

Mercury was born in the British protectorate of Zanzibar, East Africa. His parents, Bomi and Jer Bulsara,[a]Parsis from the Gujarat region of the then province of Bombay Presidency in British India.[11][b] The family surname is derived from the town of Bulsar (also known as Valsad) in southern Gujarat. As Parsis, Freddie and his family practised the Zoroastrian religion.[12] The Bulsara family had moved to Zanzibar in order for his father to continue his job as a cashier at the British Colonial Office. He had one younger sister, Kashmira.[13] were
In 1954, at the age of eight, Mercury was sent to study at St. Peter’s School,[14] an English style boarding school for boys in Panchgani near Bombay (now Mumbai), India.[15] At school, he formed a popular school band, The Hectics, for which he played piano. A friend from the time recalls that he had “an uncanny ability to listen to the radio and replay what he heard on piano”.[16] It was also at St. Peter’s where he began to call himself “Freddie”. Mercury remained in India for most of his childhood, living with his grandmother and aunt. He completed his education in India at St. Mary’s School, Bombay.[17]
At the age of 17, Mercury and his family fled from Zanzibar for safety reasons due to the 1964 Zanzibar Revolution.[6] The family moved into a small house in Feltham, Middlesex, England. Mercury enrolled at Isleworth Polytechnic (now West Thames College) in West London where he studied art. He ultimately earned a Diploma in Art and Graphic Design at Ealing Art College, later using these skills to design the Queen crest. Mercury remained a British citizen for the rest of his life.
Following graduation, Mercury joined a series of bands and sold second-hand clothes in the Kensington Market in London. He also held a job at Heathrow Airport. Friends from the time remember him as a quiet and shy young man who showed a great deal of interest in music.[18] In 1969 he joined the band Ibex, later renamed Wreckage. When this band failed to take off, he joined a second band called Sour Milk Sea. However, by early 1970 this group broke up as well.[19]
In April 1970, Mercury joined guitarist Brian May and drummer Roger Taylor who had previously been in a band called Smile. Despite reservations from the other members, Mercury chose the name “Queen” for the new band. He later said about the band’s name, “I was certainly aware of the gay connotations, but that was just one facet of it”.[1] At about the same time, he changed his surname, Bulsara, to Mercury.

Career

Singer

Although Mercury’s speaking voice naturally fell in the baritone range, he delivered most songs in the tenor[20] His vocal range extended from bass low E (E2) to coloratura soprano E-natural (E6). His belting register soaring to tenor high F (F5).[21] Biographer David Bret described his voice as “escalating within a few bars from a deep, throaty rock-growl to tender, vibrant tenor, then on to a high-pitched, perfect coloratura, pure and crystalline in the upper reaches”.[22] Spanish soprano Montserrat Caballé, with whom Mercury recorded an album, expressed her opinion that “the difference between Freddie and almost all the other rock stars was that he was selling the voice”.[23] As Queen’s career progressed, he would increasingly alter the highest notes of their songs when live, often harmonising with seconds, thirds or fifths instead. Mercury suffered from vocal fold nodules and claimed never to have had any formal vocal training.[24] range.

Songwriter

Mercury wrote 10 of the 17 songs on Queen’s Greatest Hits album: “Bohemian Rhapsody“, “Seven Seas of Rhye“, “Killer Queen“, “Somebody to Love“, “Good Old-Fashioned Lover Boy“, “We Are the Champions“, “Bicycle Race“, “Don’t Stop Me Now“, “Crazy Little Thing Called Love” and “Play the Game“.
The most notable aspect of his songwriting involved the wide range of genres that he used, which included, among other styles, rockabilly, progressive rock, heavy metal, gospel and disco. As he explained in a 1986 interview, “I hate doing the same thing again and again and again. I like to see what’s happening now in music, film and theatre and incorporate all of those things.”[25] Compared to many popular songwriters, Mercury also tended to write musically complex material. For example, “Bohemian Rhapsody” is acyclic in structure and comprises dozens of chords.[26][27] He also wrote six songs from Queen II which deal with multiple key changes and complex material. “Crazy Little Thing Called Love”, on the other hand, contains only a few chords. Despite the fact that Mercury often wrote very intricate harmonies, he also claimed that he could barely read music.[28] He wrote most of his songs on the piano and used a wide variety of different key signatures.[26]

Mercury, performing live with his bottomless microphone stand

Live performer

Mercury was noted for his live performances, which were often delivered to stadium audiences around the world. He displayed a highly theatrical style that often evoked a great deal of participation from the crowd. A writer for The Spectator described him as “a performer out to tease, shock and ultimately charm his audience with various extravagant versions of himself”.[29] David Bowie, who performed at the Freddie Mercury Tribute Concert and recorded the song “Under Pressure” with Queen, praised Mercury’s performance style, saying: “Of all the more theatrical rock performers, Freddie took it further than the rest… he took it over the edge. And of course, I always admired a man who wears tights. I only saw him in concert once and as they say, he was definitely a man who could hold an audience in the palm of his hand.”[30]
One of Mercury’s most notable performances with Queen took place at Live Aid in 1985, during which the entire stadium audience of 72,000 people clapped, sang and swayed in unison. Queen’s performance at the event has since been voted by a group of music executives as the greatest live performance in the history of rock music. The results were aired on a television program called “The World’s Greatest Gigs”.[31][32] In reviewing Live Aid in 2005, one critic wrote, “Those who compile lists of Great Rock Frontmen and award the top spots to Mick Jagger, Robert Plant, etc all are guilty of a terrible oversight. Freddie, as evidenced by his Dionysian Live Aid performance, was easily the most godlike of them all.”[33]
Over the course of his career, Mercury performed an estimated 700 concerts in countries around the world with Queen. A notable aspect of Queen concerts was the large scale involved.[25] He once explained, “We’re the Cecil B. DeMille of rock and roll, always wanting to do things bigger and better.”[25] The band were the first ever to play in South American stadiums, breaking worldwide records for concert attendance in the Morumbi Stadium in São Paulo in 1981.[34] In 1986, Queen also played behind the Iron Curtain, when they performed to a crowd of 80,000 in Budapest.[35] Mercury’s final live performance with Queen took place on 9 August 1986 at Knebworth Park in England and drew an attendance estimated as high as 300,000.[36]

Instrumentalist

Freddie Mercury playing guitar during a live concert with Queen in Frankfurt, 1984.

As a young boy in India, Mercury received formal piano training up to the age of nine. Later on, while living in London, he learned guitar. Much of the music he liked was guitar-oriented: his favourite artists at the time were The Who, The Beatles, Jimi Hendrix, David Bowie, and Led Zeppelin. He was often self-deprecating about his own skills on both instruments and from the early 1980s onward began extensively using guest keyboardists for both Queen and his solo career. Most notably, he enlisted Fred Mandel (a Canadian musician who also worked for Pink Floyd, Elton John and Supertramp) for his first solo project, and from 1985 onward collaborated with Mike Moran and Spike Edney, leaving most of the keyboard work exclusively to them.
Mercury played the piano in many of Queen’s most popular songs, including “Killer Queen“, “Bohemian Rhapsody“, “Good Old Fashioned Lover Boy“, “We Are the Champions“, “Somebody To Love” and “Don’t Stop Me Now“. He used concert grand pianos and, occasionally, other keyboard instruments such as the harpsichord. From 1980 onward, he also made frequent use of synthesizers in the studio. Queen guitarist Brian May claims that Mercury was unimpressed with his own abilities at the piano and used the instrument less over time because he wanted to walk around onstage and entertain the audience.[37] Although he wrote many lines for the guitar, Mercury possessed only rudimentary skills on the instrument. Songs like “Ogre Battle” and “Crazy Little Thing Called Love” were composed on the guitar; the latter featured Mercury playing acoustic guitar both on stage and in the studio.